Due to the fact that EVERY protein on the Immunome Protein Array is correctly folded and functional, the results from the platform are highly reproducible and consistent.
Functional Validation – Screening kinases to demonstrate auto-phosphorylation and inhibition with small molecule inhibitors.
RET is auto-phosphorylated on the Immunome Protein Array.
- Proven that proteins are actually functional on the array
- Kinase auto-phosphorylation and inhibition with small molecule inhibitor
- Receptor tyrosine kinase potency curves using staurosporine (40µM 0.15nM)
- Kinase activity correlates with published data