COVID-19 Antigens Product Range

Key Applications

Use Sengenics’ correctly folded spike, nucleocapsid or envelope COVID-19 antigens for production of a high-affinity vaccine

Development of an antigen-based COVID-19 sero-diagnostic test for patient screening or immunosurveillance purposes

Fundamental research: characterisation of full-length, correctly folded and functional SARS-CoV-2 antigens

Advantages of Sengenics’ COVID-19 Antigens and Tests

Correctly folded antigens lead to better immunogenic response

Since most antibodies are thought to recognise discontinuous epitopes on their target proteins, it’s critical that antigens used in serological assays or presented to B-cells for antibody-based vaccine development are in a natively-folded form. The use of our KREX™ technology for the production of the SARS-CoV-2 antigens will ensure these antigens are correctly folded, preserving all conformational antibody binding sites.

Higher sensitivity and specificity than antibody/RT-PCR-based test

Serological-based tests enable the quantification of IgM and other types of Immunoglobulin. In the case of infectious diseases, IgM is the first antibody produced by the body to fight a new infection. Therefore, our test will overcome the limitations of current rtPCR tests. It is also crucial for immunosurveillance purposes, during both pre- and post-infection periods, particularly for disease management during a pandemic.

Product Description

All antigens are expressed in sf9 insect cells using the patented KREX functional proteomics technology. Viral antigens are full-length, correctly folded, functional, with both conformational and non-conformational antibody binding sites preserved. Each antigen is supplied as either lysate or purified protein.


Code Product Description Data Sheet Order Link
39501 Recombinant SARS-CoV-2 Nucleocapsid Protein
GenBank accession code: MN908947.3, Protein sequence length (aa): 419
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39502 Recombinant SARS-CoV-2 Spike Protein
GenBank accession code: YP_009724390.1, Protein sequence length (aa): 1273
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39503 Recombinant SARS-CoV-2 Spike (R682S) Protein
GenBank accession code: YP_009724390.1, Protein sequence length (aa): 1273
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39504 Recombinant SARS-CoV-2 Envelope Protein
GenBank accession code: QHD43418.1, Protein sequence length (aa): 75
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39505 Recombinant SARS-CoV (2004) Nucleocapsid Protein
GenBank accession code: NP_828858.1, Protein sequence length (aa): 422
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39506 Recombinant MERS-CoV Nucleocapsid Protein
GenBank accession code: AKQ21082.1, Protein sequence length (aa): 413
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39507 Recombinant Influenza A and B Ha Proteins Download
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39511 Recombinant CoV-HKU1 Nucleocapsid Protein
GenBank accession code: ABD75533.1, Protein sequence length (aa): 441
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39512 Recombinant CoV-HKU2 Nucleocapsid Protein
GenBank accession code: ABQ57212.1, Protein sequence length (aa): 375
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39513 Recombinant CoV-HKU8 Nucleocapsid Protein
GenBank accession code: ACA52175.1, Protein sequence length (aa): 422
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39514 Recombinant CoV-HKU9 Nucleocapsid Protein
GenBank accession code: ABN10915.1, Protein sequence length (aa): 468
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39515 Recombinant CoV-HKU10 Nucleocapsid Protein
GenBank accession code: AFU92082.1, Protein sequence length (aa): 399
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39516 Recombinant CoV-229E Nucleocapsid Protein
GenBank accession code: AGW80945.1, Protein sequence length (aa): 389
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39517 Recombinant CoV-NL63 Nucleocapsid Protein
GenBank accession code: AFD98817.1, Protein sequence length (aa): 377
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39518 Recombinant CoV-PEDV Nucleocapsid Protein
GenBank accession code: AAK38660.1, Protein sequence length (aa): 441
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39519 Recombinant CoV-PRCV Nucleocapsid Protein
GenBank accession code: ABG89315.1, Protein sequence length (aa): 382
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39520 Recombinant CoV-Myotis Nucleocapsid Protein
GenBank accession code: AGT21337.1, Protein sequence length (aa): 425
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39521 Recombinant CoV-Hippo Nucleocapsid Protein
GenBank accession code: ADY17917.1, Protein sequence length (aa): 419
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FEATURED PRODUCTS

IMMUNOME Protein Array

High-throughput multiplexed autoantibody screening protein array containing 1600+
autoantigens

ImmuSAFE COVID Tests

Contains correctly folded antigens from SARS-CoV-2 and 25 other Corona and Influenza
viruses

SARS-CoV-2 Antigens

7 Recombinant SARS-CoV-2 antigens expressed using the patented KREX™ functional proteomics technology

DOWNLOADS

Resources to access our technology

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SOLUTIONS

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Sengenics - Functional Proteomics | Krex Technology | Protein Array Supplier

Sengenics is a functional proteomics company that leverages its patented KREX technology for production of full-length, correctly folded and functional proteins. The key application of KREX is the discovery of autoantibody biomarkers for two core medical use cases:  stratification of patients undergoing treatment with autoimmune or cancer drugs and identification of autoantibody biomarkers that may be used to diagnose cancer, autoimmune or neurodegenerative conditions. Some autoantibodies that are identified as diagnostic biomarkers may be protective and have potential in themselves as therapeutic biomolecules.

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