ImmuSAFE™ COVID+ Biochip

Product Specifications


Product Name ImmuSAFE™ COVID+ Biochip Test
Product Name ImmuSAFE™ COVID+ Biochip Test
Platform Sengenics’ KREX™ proprietary surface which preserves protein folding and inhibits binding of non-specific proteins
Content Multiple domains of SARS-CoV-2 Nucleocapsid and Spike proteins including full-length and numerous truncated versions
Number of Arrays 24 arrays per slide (24 samples per slide)
Sample Type Human Serum/Plasma
Assay Type Single-colour fluorescently-labelled antibody assay
Dual-colour fluorescently-labelled antibody assay
System Compatibility Any open-format microarray scanner (Example: Agilent, InnoScan, Genepix or Tecan Scanner)

Control Probes:

  • Positive control
    1. Cy3-BSA
    2. Cy5-BSA
    3. IgA (positive control for total immunoglobulins detection)
    4. IgG (positive control for IgG and total immunoglobulins detection)
    5. IgM (positive control for IgM and total immunoglobulins detection)
  • Negative control
    1. IgA (negative control for IgG and IgM detection)
    2. IgG (negative control for IgM detection)
    3. IgM (negative control for IgG detection)
    4. Negative control probe for total immunoglobulins detection

ImmuSAFE is able to determine titre and position of antibodies.

Figure 1: Overall breadth of epitope coverage in all 50 cases. All positive samples showed antibody reactivity towards at least 1 domain and displayed diverse locality distribution. The numerical value in each red dot represents the number of total antigens with positive antibody reactivity.

 

ImmuSAFE data shows that antibody coverage and titre increases with age.

Figure 2: A positive correlation between increasing age of COVID-19 patients and higher Epitope Coverage scores (EPC) was observed. The figure on the bar plot represents the average number of antigens with positive immunoreactivity exhibited by each age group.

Figure 3: A positive correlation was evident between COVID-19 patients aged above 40 and antibody titre towards SARS-CoV-2 N antigens

FEATURED PRODUCTS

IMMUNOME Protein Array

High-throughput multiplexed autoantibody screening protein array containing 1600+
autoantigens

ImmuSAFE COVID Tests

Contains correctly folded antigens from SARS-CoV-2 and 25 other Corona and Influenza
viruses

SARS-CoV-2 Antigens

7 Recombinant SARS-CoV-2 antigens expressed using the patented KREX™ functional proteomics technology

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Sengenics - Functional Proteomics | Krex Technology | Protein Array Supplier

Sengenics is a functional proteomics company that leverages its patented KREX technology for production of full-length, correctly folded and functional proteins. The key application of KREX is the discovery of autoantibody biomarkers for two core medical use cases:  stratification of patients undergoing treatment with autoimmune or cancer drugs and identification of autoantibody biomarkers that may be used to diagnose cancer, autoimmune or neurodegenerative conditions. Some autoantibodies that are identified as diagnostic biomarkers may be protective and have potential in themselves as therapeutic biomolecules.

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