The Fundamental Principle of KREX

  • The fundamental principle of our technology is that when the protein of interest is correctly folded, it co-translationally drives the correct folding of BCCP. Which then becomes biotinylated and allows the fusion protein to become attached to the surface.
  • On the other hand, when the protein of interest is grossly misfolded, it co-translationally drives misfolding of BCCP so it can no longer become biotinylated, preventing it from attaching to the surface. These proteins simply get washed away.

KREX Technology Overview

Surface chemistry of KREX protein arrays

  • BCCP-tagged, biotinylated KREX proteins are immobilised onto a customised streptavidin-coated hydrogel surface
  • KREX proteins retain their folded structure and function as if they are present in an aqueous environment
  • Proteins behave as if they are in free solution


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FEATURED PRODUCTS

IMMUNOME
Protein Array

High-throughput
sero-profiling platform

CTA
Protein Array

Screening of
cancer-testis antigens

OncoREX p53
Cancer Array

Cancer drug
screening and discovery

Custom
Protein Array

Flexible format for
high-throughput screening

Sengenics is a functional proteomics company that leverages its patented KREX technology for production of full-length, correctly folded and functional proteins. The key application of KREX is the discovery of autoantibody biomarkers for two core medical use cases:  stratification of patients undergoing treatment with autoimmune or cancer drugs and identification of autoantibody biomarkers that may be used to diagnose cancer, autoimmune or neurodegenerative conditions. Some autoantibodies that are identified as diagnostic biomarkers may be protective and have potential in themselves as therapeutic biomolecules.

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