OncoREX p53 Cancer Array

Product number 35000

Pricing


CodeProduct Description
35000Ap53 Cancer Array Service
35000p53 Cancer Array Kit

Description

OncoREX™ p53 Cancer Array is a protein array which utilises the patented Sengenics KREX™ functional proteomics technology. All 100 p53 mutant variant proteins on the OncoREX™ p53 Cancer Array are correctly folded and functional as they are expressed as fusion proteins with biotin carboxyl carrier protein (BCCP) which acts as a folding marker and solubility enhancer. The arrays are coated with a proprietary surface which preserves protein folding and inhibits binding of non-specific proteins.

3 key applications of the OncoREX™ p53 cancer array:

1. Discovering new compounds that can restore the function of mutant p53
2. Direct functional correlation between genotype and phenotype
3. Determine the effect of p53 mutations on binding of autoantibodies and antibodies


Specifications

Product name: OncoREX™ p53 Cancer Array

Minimum Order: 30 slides

Slide Type: Streptavidin-coated glass slide

Species: Human

Storage: Store for up to 12 months at -20°c

Delivery lead time: 4 weeks

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SOLUTIONS

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Sengenics is a functional proteomics company that leverages its patented KREX technology for production of full-length, correctly folded and functional proteins. The key application of KREX is the discovery of autoantibody biomarkers for two core medical use cases:  stratification of patients undergoing treatment with autoimmune or cancer drugs and identification of autoantibody biomarkers that may be used to diagnose cancer, autoimmune or neurodegenerative conditions. Some autoantibodies that are identified as diagnostic biomarkers may be protective and have potential in themselves as therapeutic biomolecules.

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