Autoantibody Biomarker Discovery
Systemic Lupus Erythematosus (SLE)
Identification of novel autoantibodies in SLE and stratification of subgroups of SLE individuals.
4 SLE subgroups were categorised based on hierarchical clustering and principal component analysis (PCA) with known autoantigens such as TROVE2 (Ro60) and SSB (La) forming a single cluster and novel TGF-β signalling (SMAD2 and SMAD5) and TLR signalling (My88) autoantigens forming another cluster.
Drug Companion Diagnostics
Checkpoint Inhibitor Melanoma Trial
Metastatic melanoma, BRAF mutant patients, treated with experimental checkpoint inhibitor drugs.
Stratified patients into 3 cohorts (responsive, non-responsive, toxic).
Protein Interaction Assays
DNA-Protein Interaction Study
p53 microarray printed onto a neutravidin-derivatised dextran hydrogel surface probed with Cy3-labelled GADD45 duplex oligo
Quantitative parallel thermodynamic analysis revealed previously unknown functional effects of mutation on p53 protein-DNA interaction
Differential DNA binding activity of p53 mutant proteins
Quantitative analysis unravels mechanistic differences between ‘loss of function’ mutations
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