KREX Publications

Publications : Autoimmune Diseases


Cancer Publication Links

Autoantibodies Targeting TLR and SMAD Pathways Define New Subgroups in Systemic Lupus Erythematosus

Lewis, Myles J. et al. 2018. “Autoantibodies Targeting TLR and SMAD Pathways Define New Subgroups in Systemic Lupus Erythematosus.” Journal of Autoimmunity 91: 1–12. https://linkinghub.elsevier.com/retrieve/pii/S0896841118300234
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Identification of Novel Native Autoantigens in Rheumatoid Arthritis

Poulsen, Thomas B. G. et al. 2020 “Identification of Novel Native Autoantigens in Rheumatoid Arthritis.” Biomedicines 2020, 8(6), 141. https://www.mdpi.com/2227-9059/8/6/141/htm
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Detection of putative autoantibodies in systemic lupus erythematous using a novel native-conformation protein microarray platform

Mak, A., Kow, N. Y., Ismail, N. H., Anuar, N. D., Rutt, N. H., & Cho, J. (2020). Detection of putative autoantibodies in systemic lupus erythematous using a novel native-conformation protein microarray platform. 1–7. https://doi.org/10.1177/0961203320959696
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Publications : Cancer


Cancer Publication Links
Functional Protein Microarrays for Parallel Characterisation of P53 Mutants

Functional Protein Microarrays for Parallel Characterisation of P53 Mutants

Boutell, Jonathan M. et al. 2004. “Functional Protein Microarrays for Parallel Characterisation of P53 Mutants.” PROTEOMICS 4(7): 1950–58. http://doi.wiley.com/10.1002/pmic.200300722.
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Seromic Analysis of Antibody Responses in Non-Small Cell Lung Cancer Patients and Healthy Donors Using Conformational Protein Arrays

Seromic Analysis of Antibody Responses in Non-Small Cell Lung Cancer Patients and Healthy Donors Using Conformational Protein Arrays

Gnjatic, Sacha et al. 2009. “Seromic Analysis of Antibody Responses in Non-Small Cell Lung Cancer Patients and Healthy Donors Using Conformational Protein Arrays.” Journal of Immunological Methods 341(1–2): 50–58. http://linkinghub.elsevier.com/retrieve/pii/S0022175908003244
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Protein Function Microarrays: Design, Use and Bioinformatic Analysis in Cancer Biomarker Discovery and Quantitation

Protein Function Microarrays: Design, Use and Bioinformatic Analysis in Cancer Biomarker Discovery and Quantitation

Duarte, Jessica, Jean-Michel Serufuri, Nicola Mulder, and Jonathan Blackburn. 2013. “Protein Function Microarrays: Design, Use and Bioinformatic Analysis in Cancer Biomarker Discovery and Quantitation.” In , 39–74. http://link.springer.com/10.1007/978-94-007-5811-7_3
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Serologic Autoantibodies as Diagnostic Cancer Biomarkers — A Review

Serologic Autoantibodies as Diagnostic Cancer Biomarkers — A Review

Zaenker, P., and M. R. Ziman. 2013. “Serologic Autoantibodies as Diagnostic Cancer Biomarkers–A Review.” Cancer Epidemiology Biomarkers & Prevention 22(12): 2161–81. http://cebp.aacrjournals.org/cgi/doi/10.1158/1055-9965.EPI-13-0621
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Development Of A Novel, Quantitative Protein Microarray Platform for the Multiplexed Serological Analysis of Autoantibodies to Cancer-Testis Antigens

Development Of A Novel, Quantitative Protein Microarray Platform for the Multiplexed Serological Analysis of Autoantibodies to Cancer-Testis Antigens

Beeton-Kempen, Natasha et al. 2014. “Development of a Novel, Quantitative Protein Microarray Platform for the Multiplexed Serological Analysis of Autoantibodies to Cancer-Testis Antigens.” International journal of cancer 135(8): 1842–51. http://www.ncbi.nlm.nih.gov/pubmed/24604332
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Novel Potential Serological Prostate Cancer Biomarkers Using CT100+ Cancer Antigen Microarray Platform in a Multi-Cultural South African Cohort

Novel Potential Serological Prostate Cancer Biomarkers Using CT100+ Cancer Antigen Microarray Platform in a Multi-Cultural South African Cohort

Adeola, Henry A et al. 2016. “Novel Potential Serological Prostate Cancer Biomarkers Using CT100+ Cancer Antigen Microarray Platform in a Multi-Cultural South African Cohort.” Oncotarget 7(12): 13945–64. http://view.ncbi.nlm.nih.gov/pubmed/26885621
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Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin followed by Ipilimumab in Patients with Advanced Metastatic Melanoma

Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin followed by Ipilimumab in Patients with Advanced Metastatic Melanoma

Da Gama Duarte, Jessica et al. 2018. “Autoantibodies May Predict Immune-Related Toxicity: Results from a Phase I Study of Intralesional Bacillus Calmette–Guérin Followed by Ipilimumab in Patients with Advanced Metastatic Melanoma.” Frontiers in Immunology 9. http://journal.frontiersin.org/article/10.3389/fimmu.2018.00411/full
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A Diagnostic Autoantibody Signature for Primary Cutaneous Melanoma

A Diagnostic Autoantibody Signature for Primary Cutaneous Melanoma

Zaenker, Pauline et al. 2018. “A Diagnostic Autoantibody Signature for Primary Cutaneous Melanoma.” Oncotarget 9(55): 30539–51. http://www.ncbi.nlm.nih.gov/pubmed/30093967
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B cells and Antibody Production in Melanoma

B cells and Antibody Production in Melanoma

Da Gama Duarte, Jessica, Janique M. Peyper, and Jonathan M. Blackburn. 2018. “B Cells and Antibody Production in Melanoma.” Mammalian Genome. http://link.springer.com/10.1007/s00335-018-9778-z
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Publications : Neurodegenerative Diseases


Cancer Publication Links

Augmentation of Autoantibodies by Helicobacter pylori in Parkinson’s Disease Patients May Be Linked to Greater Severity

Suwarnalata, Gunasekaran et al. 2016. “Augmentation of Autoantibodies by Helicobacter pylori in Parkinson’s Disease Patients May Be Linked to Greater Severity.” PloS one 11(4). http://view.ncbi.nlm.nih.gov/pubmed/27100827
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Publications : Infectious Diseases


Cancer Publication Links

Autoantibody Profile of Patients Infected with Knowlesi Malaria

Liew, Jonathan et al. 2015. “Autoantibody Profile of Patients Infected with Knowlesi Malaria.” Clinica chimica acta; international journal of clinical chemistry 448: 33–38. http://view.ncbi.nlm.nih.gov/pubmed/26086445
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Identifying Protein Biomarkers in Predicting Disease Severity of Dengue Virus Infection Using Immune-Related Protein Microarray

Soe, Hui Jen et al. 2018. “Identifying Protein Biomarkers in Predicting Disease Severity of Dengue Virus Infection Using Immune-Related Protein Microarray.” Medicine 97(5): e9713. http://insights.ovid.com/crossref?an=00005792-201802020-00013
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COVID-19 Antibody Testing: From Hype to Immunological Reality

Blackburn, Jonathan et al. 2020. “COVID-19 Antibody Testing: From Hype to Immunological Reality.” S Afr Med J. Published online 27 July 2020. https://doi.org/10.7196/SAMJ.2020.v110i9.15155
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Quantitative, Epitope-specific, Serological Screening of COVID-19 Patients Using a Novel Multiplexed Array-based Immunoassay Platform

Blackburn, J., Anuar, N., Tan, T., Nel, A., Smith, M., Ellan, K., … Zain, R. (2020). Quantitative, Epitope-specific, Serological Screening of COVID-19 Patients Using a Novel Multiplexed Array-based Immunoassay Platform. MedRxiv, 40170, 2020.09.25.20201269. https://doi.org/10.1101/2020.09.25.20201269
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Publications : Other Diseases


Cancer Publication Links

A Novel Method to Identify Autoantibodies against Putative Target Proteins in Serum from beta-Thalassemia Major: A Pilot Study

Sumera, Afshan et. al. 2020 “A Novel Method to Identify Autoantibodies against Putative Target Proteins in Serum from betaThalassemia Major: A Pilot Study.” Biomedicines 2020, 8(5), 97; https://doi.org/10.3390/biomedicines8050097
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Publications : Technology


Cancer Publication Links

Protein Function Microarrays for Customised Systems-Oriented Proteome Analysis

Blackburn, Jonathan M, and Aubrey Shoko. 2011. “Protein Function Microarrays for Customised Systems-Oriented Proteome Analysis.” Methods in molecular biology (Clifton, N.J.) 785: 305–30. http://www.ncbi.nlm.nih.gov/pubmed/21901609
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Advances in the Development of Human Protein Microarrays

Duarte, Jessica G., and Jonathan M. Blackburn. 2017. “Advances in the Development of Human Protein Microarrays.” Expert Review of Proteomics 14(7): 627–41. https://www.tandfonline.com/doi/full/10.1080/14789450.2017.1347042.
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Autoantibody-Based Diagnostic Biomarkers: Technological Approaches to Discovery and Validation

Aziz, Farhanah et al. 2018. “Autoantibody-Based Diagnostic Biomarkers: Technological Approaches to Discovery and Validation.” IntechOpen DOI: 10.5772/intechopen.75200 https://www.intechopen.com/books/autoantibodies-and-cytokines/autoantibody-based-diagnostic-biomarkers-technological-approaches-to-discovery-and-validation
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Applications of Functional Protein Arrays for Detection and Development of Autoantibody-based Diagnostics and Therapeutics

Aziz, Farhanah et al. 2018. “Applications of Functional Protein Arrays for Detection and Development of Autoantibody-based Diagnostics
and Therapeutics.” International Biopharmaceutical Industry https://www.biopharmaceuticalmedia.com/applications-of-functional-protein-arrays-for-detection-and-development-of-autoantibody-based-diagnostic-and-therapeutic/
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Sengenics - Functional Proteomics | Krex Technology | Protein Array Supplier

Sengenics is a functional proteomics company that leverages its patented KREX technology for production of full-length, correctly folded and functional proteins. The key application of KREX is the discovery of autoantibody biomarkers for two core medical use cases:  stratification of patients undergoing treatment with autoimmune or cancer drugs and identification of autoantibody biomarkers that may be used to diagnose cancer, autoimmune or neurodegenerative conditions. Some autoantibodies that are identified as diagnostic biomarkers may be protective and have potential in themselves as therapeutic biomolecules.

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