Because all the proteins on KREX protein arrays are correctly folded, conformational as well as non-conformational epitopes are available for binding to antibodies. Since 90% of autoantibody binding sites are conformational in nature, if the protein is not full length or not correctly folded, other protein arrays actually lead to the loss of binding to these conformational epitopes. Using our KREX protein arrays ensure that the binding of antibodies to not just linear, non-conformational epitopes but also discontinuous conformational epitopes.
The main advantage of the KREX-based array is that the immobilised protein is folded in its native conformation, due to the BCCP fusion and the absence of physical protein purification which may affect epitope exposure for recognition.